Custom Peptides
Cayman Chemical 1 2 3TrIundecnoyl GlycRol 10mg
A triacylglycerol; dietary administration prevents fasting-induced decreases in plasma glucose, alanine, and insulin levels, as well as the ratio of insulin to glucagon, in rats
Cayman Chemical 5 7 3 4 5Pentamethoxyflav 10mg
A flavonoid with diverse biological activities; inhibits pancreatic lipase in a cell-free assay; reduces lipid accumulation in 3T3-L1 adipocytes; inhibits transactivation of Nrf2 in a reporter assay using HEK293T cells at 10, 25, or 50 µM; sensitizes cisplatin-resistant A549 NSCLC cells to cisplatin; inhibits LPS-induced NO production in RAW 264.7 macrophages and GES-1 cells; decreases blood glucose levels and renal fibrosis in a rat model of STZ-induced diabetes at 5 mg/kg
Cayman Chemical BTS-54-505hydrochlorIde 10mg
An active metabolite of sibutramine; inhibits norepinephrine, 5-HT, and dopamine uptake in rat cortical synaptosomes (IC50s = 0.066, 5.1, and 0.61 µM, respectively); prevents reserpine-induced ptosis in rats (ED50 = 3.7 mg/kg); decreases immobility in the Porsolt learned helplessness test in mice at 10 mg/kg; increases colonic temperature and decreases food intake in rats at 10 mg/kg
Cayman Chemical S-SulfocysteIn 10mg
An NMDA receptor agonist; selective for the NMDA receptor over the AMPA receptor in radioligand binding assays (EC50s = 8.2 and 59 µM, respectively); cytotoxic to primary mouse neuronal cells at 200 µM; induces calcium influx and activates calpain-dependent degradation of gephyrin at 100 µM; increases swimming and seizure-like movements, indicating neurodegeneration, in zebrafish larvae at 2 mM three days post-fertilization; urinary and plasma levels of S-sulfocysteine are increased in patients with MoCD
Cayman Chemical Betulonaldehyde 10mg
A pentacyclic triterpenoid; active against P. falciparum (IC50 = 3.36 UG/ml); cytotoxic to NCI H187 and Vero cells (IC50s = 19.23 and 17.09 UG/ml, respectively); reduces TPA-induced EAr edema in mice at 1 mg/ear; has also been used a precursor in the semisynthesis of C-2 and C-28 betulonic aldehyde derivatives
Cayman Chemical ValerylLcarnItInchLRIde 10mg
A short-chain acylcarnitine; levels increase in the serum of rhesus monkeys following exposure to 7 and 10 Gy of ionizing radiation
Cayman Chemical BeauverIcIn 10mg
A mycotoxin which is cytotoxic against insect cells, killing the insect cell line SF-9 with a 50% cytotoxic concentration of 2.5 μM; induces apoptosis in mammalian cells with an IC50 value of 4.5 μM
Cayman Chemical LumIracoxIb 10mg
A selective inhibitor of COX-2 over COX-1 (IC50s = 0.13 and 67 µM, respectively); reduces increases in the levels of PGE2 induced by IL-1β in human dermal fibroblasts (IC50 = 0.14 µM), as well as in LPS-stimulated RAW 264.7 cells at 1-100 µM; decreases LPS-induced increases in the levels of PGE2 in a rat model of air pouch inflammation at 3 and 10 mg/kg; reduces M. tuberculosis-induced increases in hind paw volume and the radiological and histopathological severity of arthritic lesions in a rat model of chronic arthritis at 2 mg/kg
Cayman Chemical PImecrolImus 10mg
A macrolactam that binds to macrophilin-12 and inhibits calcineurin as well as prolyl isomerase; the activation of T cells by allogeneic dendritic cells (IC50 = 0.55 nM) and suppresses the generation of pro-inflammatory cytokines; used in countering inflammatory skin diseases, such as eczema and psoriasis
Cayman Chemical JWH 250 5hydroxyIndl meta 10mg
Expected to be a metabolite of JWH 250 that would be detectable both in serum and in urine; intended for research and forensic applications
BIORTUS USA INC Human IRAK4 Protein, 100UG
Gene Name: IRAK4. Uniprot: Q9NWZ3. Construct: His-TEV-IRAK4(E154-S460 end). Expression Host: Insect cell. Purity: 90%.
Cayman Chemical 4FluoroIsocathInonhydroch 10mg
A compound which structurally mimics substituted cathinones and phenethylamines; a potential designer drug of abuse; intended for research and forensic applications
Cayman Chemical SPAA-52amonIum salt 10mg
An LMW-PTP inhibitor (Ki = 1.2 nM); greater than 8,000-fold selective for LMW-PTP over 24 phosphatases at 10 µM
Cayman Chemical 1 5-DIcaffeoylquInIc AcId 10mg
An HIV-1 integrase inhibitor and free radical scavenger; inhibits HIV-1 integrase 3' end processing, end joining, and disintegration (IC50s = 0.35, 0.56, and 0.84 μg/ml, respectively); inhibits HIV-1 replication in MT-2 cells (ED50 = 2 μg/ml); dose-dependently reduces the level of free radicals released by FMLP stimulation of PMN cells at 0.25-1 μM; dose-dependently increases cell survival and GSH levels and decreases ROS and LDH release when rat cerebral astrocytes in an oxygen-glucose deprivation/reperfusion assay using rat cerebral astrocytes at 5-100 μM
Cayman Chemical 1 3DIpalmItoleoyl GlycRol 10mg
A diacylglycerol with palmitoleic acid at the sn-1 and sn-3 positions; selectively inhibits α-glucosidase from S. cerevisiae over rat enzyme (IC50s = 4.45 and 9,326.5 μM, respectively); has been used in the formation of lipid bilayers to study the effects of membrane composition and valinomycin on membrane potential